In vitro and in vivo analysis of the mode of action of a new Pseudomonas aeruginosa antipersister molecule KU Leuven
The increasing rate of antibiotic resistance, together with the limited number of novel antibacterial compounds, is causing a true public health crisis where treatment options for patients infected with multidrug-resistant bacteria are down to only a few last-line antibiotics. Greatly contributing to the difficult treatment of these bacterial infections is the presence of a small fraction of persister cells; phenotypical variants which are ...