Projects
Liver and brain organoids to model human pluripotent stem cell tumorigenesis Vrije Universiteit Brussel
stem cell-derived (hPSC) cells is their potential for tumour formation.
Up to now, research has focused on the possibility that poorly
differentiated or progenitor cells initiate tumour formation upon
transplantation. Conversely, hPSC are prone to acquiring genetic
abnormalities that are very similar to those identified in cancers and
...
Sinusoidal cell communication in liver fibrosis Vrije Universiteit Brussel
The only treatment for end-stage liver disease is a liver transplantation. While in current clinical
trials, there are some promising drugs in the pipe-line a complete resolution of liver fibrosis is not observed. A better ...
Extensive characterization of different human liver progenitor cell populations Vrije Universiteit Brussel
Food allergy after pediatric liver transplantation: role of the immature immune system and liver in oral tolerance Ghent University
Food allergy (FA) after pediatric liver transplantation (LT) is a frequent problem occurring in more than 20% of patients. Symptoms are often severe with a major impact on quality of life. In-depth study of patient characteristics and literature revealed that post transplant FA is primarily associated with LT (and not so much with other solid organ transplants), young age at time of transplantation and use of tacrolimus as maintenance ...
Study of the NF-kB inhibitory protein A20 in the liver and liver pathologies like hepatocellular carcinoma Ghent University
The transcription factor NF-KB is of crucial importance for inflammatory signaling, adaptive and innate immunity, development, cell survival and cell proliferation. Because of its function in a broad range of cellular processes, NF-KB signaling pathways need to be tightly regulated. One of the proteins known to play a key role in the termination of NF-KB signaling is A20, a protein which is induced by NF-KB and will terminate the signaling ...
RECONDITIONING OF TRANSPLANT LIVERS USING NORMOTHERMIC MACHINE PERFUSION AND PARACRINE FACTORS OF HUMAN LIVER STEM CELLS KU Leuven
The success of liver transplantation as a curative treatment for irreversible liver failure has led to a dramatic shortage in suitable donor organs. To expand the donor pool, livers previously considered unsuitable for transplantation are now increasingly used. Such ‘high-risk’ grafts are more susceptible to ischemia reperfusion injury (IRI), that results from consecutive interruption and reinstitution of blood and oxygen during the ...
Study of the origins and functions of distinct hepatic macrophage subsets in the pathogenesis of acute liver failure. Ghent University
Paracetamol is a common household medication used to relieve pain. While it is safe and effective in therapeutic doses, when these doses are exceeded this can lead to acute liver failure as one of the breakdown products of paracetamol is toxic to the liver. This leads to the death of hepatocytes, the structural cells of the liver which in turn causes activation of the local immune system and local inflammation. This inflammation further ...