Developing a preclinical test platform that incorporates interpatient variability to lower the attrition rate in antimicrobial drug development Ghent University
The high attrition rate in drug development is a major issue for the pharmaceutical industry. Of particular concern is the high failure rate in clinical phase 2 and 3. At this point, failure is disastrous from an economic point of view, leading to an outrageous general cost to bring a compound to the market. Providing predictive in vitro tests in a preclinical stage is generally acknowledged to lower the chances of failure in clinical ...