Publications
Monitoring Inflammation, Humoral and Cell-mediated Immunity in Pancreas and Islet Transplants Vrije Universiteit Brussel
Type 1 diabetes (T1D) is caused by the chronic autoimmune destruction of insulin producing beta cells. Beta cell replacement therapy through whole pancreas or islet transplantation is a therapeutic option for patients in which a stable glucose control is not achievable with exogenous insulin therapy. Long-term insulin independence is, however, hampered by the recipient immune response that includes activation of inflammatory pathways and ...
Hybrid immunity overcomes defective immune response to COVID-19 vaccination in kidney transplant recipients Institute of Tropical Medicine
Comorbidities and immunosuppressive therapies are associated with reduced immune responses to primary COVID-19 mRNA vaccination in kidney transplant recipients (KTRs). In healthy individuals, prior SARS-COV-2 infection is associated with increased vaccine responses, a phenotype called hybrid immunity. In this study, we explored the potential influence of immune suppression on hybrid immunity in KTRs.
Methods
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Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity Ghent University
How to recognize inborn errors of immunity in a child presenting with a malignancy : guidelines for the pediatric hemato-oncologist Ghent University Vrije Universiteit Brussel
The effect of maternal supply of rumen-protected protein to Holstein Friesian cows during the dry period on the transfer of passive immunity and colostral microbial composition Ghent University Research Institute for Agriculture, Fisheries and Food
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells Vrije Universiteit Brussel
mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA expression and endows the vaccine with adjuvant properties that drive potent antibody responses. Effective cancer vaccines require long-lived, qualitative CD8 T cell responses instead of antibody responses. Systemic vaccination appears to be the most effective route, but ...