Systematic identification of genetic interactions in plants using a combinatorial CRISPR screening pipeline Ghent University
Genetic interaction occurs when a gene’s effect is modified by one or several other genes. Redundancy is one type of interaction and it interferes with investigations into gene function as mutations in single genes do not always result in clear or obvious phenotypes. Genetic interactors have been systematically identified in yeast and mammals, but only a few experiments have been reported in plants. This is due to a lack of high-throughput ...