Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a neurodegenerative brain disorder that can be accompanied by signs of amyotrophic lateral sclerosis (ALS).
OBJECTIVE: To identify a novel gene for FTLD-ALS.
DESIGN: Genome-wide linkage study in a multiplex family with FTLD-ALS with subsequent fine mapping and mutation analyses.
SETTING: Memory Clinic of the Middelheim General Hospital.
PATIENTS: An extended ...