Projects
Dysregulated cell death and efferocytosis in chronic obstructive pulmonary disease (COPD) Ghent University
Chronic Obstructive Pulmonary Disease (COPD) is globally the third leading cause of death. COPD is characterized by a persistent and usually progressive airflow limitation, that is associated with an abnormal inflammatory response of the lungs to mainly cigarette smoke, causing obstruction of the small airways and alveolar destruction (i.e., emphysema). Drugs that slow down the disease progression are still lacking, because of a poor ...
LUNG VOLUME REDUCTION TO TREAT SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A MULTIDISCIPLINARY DIAGNOSTIC AND INTERVENTIONAL APPROACH FROM REFERRAL TO FOLLOW- UP. KU Leuven
Establishing and countering the effects of intermittent hypoxia in pediatric obstructive sleep apnea and obesity: the Snore Enough? Snore More! project. University of Antwerp
Impact of Chronic Obstructive Pulmonary Disease (COPD) severity and disease phenotypes on bronchial epithelial cell immune responses to (non-)infective triggers. University of Antwerp
Destruction of Per- and Polyfluoroalkyl Substances (PFAS) by Advanced Reduction Processes (ARPs) KU Leuven
Ozonation is a mature advanced oxidation processes (AOPs) which has been extensively applied in water/wastewater treatment. However, a single ozonation always suffers some drawbacks, such as a low solubility and stability of ozone in the liquid phase, an incomplete mineralization of contaminants, and a comparatively high energy consumption. These would render both a low mass transfer efficiency and a confined degradation of pollutants. The ...
Photo-induced destruction of protein aggregates and liquefaction of the vitreous humour using light sensitive nanomaterials. Ghent University
With aging there is progressive aggregation of collagen in the vitreous. When collagen aggregates (‘floaters’) become too large they block sight, which negatively impacts vision. Photo-ablation, the treatment of the aggregates with strong (nanosecond) pulsed-laser, is a current practice. Though significant room remains for a more effective and safer treatment. This project aims to destroy aggregates through the combined use of (i) laser ...
Development of a predictive model for endotype-based patient selection for obstructive sleep apnea treatment. University of Antwerp
PhD Lung-on-chip to capture cell interplay in chronic obstructive lung disease KU Leuven
COPD is triggered by exposure to inhaled harmful environmental agents with cigarette smoking representing the major contributor. The disease is characterized by progressive airflow obstruction and chronic neutrophilic inflammation in the airway lumen, and is complicated by recurrent infectious exacerbations. Abnormal responses of the airway epithelium to the environmental triggers are believed to contribute to the pathogenesis of COPD and the ...