Projects

Soft tissue sarcomas (STS) represent a heterogeneous group of rare, malignant tumors of mesenchymal origin, which compromises more than 70 histological subtypes. Despite their extensive histological and molecular variety, the treatment of these patients is rather uniform, driven by the stage of disease at diagnosis instead of rational drug-targeting. While surgery with or without radiotherapy is the mainstay of treatment for patients with ...

C-Nucleosides are an important family of compounds with promising biological activities. In C-nucleosides, the labile C-N glycosidic linkage of classical N-nucleosides is replaced by a more stable C-C bond, which makes C-nucleosides resistant against hydrolysis. Some naturally occurring C-nucleosides such as formycin and showdomycin are potent antibiotics, while pseudouridine, an isomer of uridine, is able to stabilize RNA duplexes by ...