Synthesis and biological evaluation of C-nucleoside analogues KU Leuven
C-Nucleosides are an important family of compounds with promising biological activities. In C-nucleosides, the labile C-N glycosidic linkage of classical N-nucleosides is replaced by a more stable C-C bond, which makes C-nucleosides resistant against hydrolysis. Some naturally occurring C-nucleosides such as formycin and showdomycin are potent antibiotics, while pseudouridine, an isomer of uridine, is able to stabilize RNA duplexes by ...