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Spin State Crossover, Vibrational, Computational, and Structural Studies of FeII 1-Isopropyl-1H-tetrazole Derivatives KU Leuven
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Mononuclear complexes of formula [Fe(iptz)6]X2 {X = BF4– (1), ClO4– (2); iptz = 1-isopropyl-1H-tetrazole} have been synthesized and characterized spectroscopically and structurally. These materials display a gradual and incomplete spin conversion around 95 K on cooling, as well as a reversible thermochromic effect. This magnetic behavior was satisfactorily simulated using the Sorai and Seki ...
Evaluation of the effects of olodaterol on exercise endurance in patients with chronic obstructive pulmonary disease: results from two 6-week crossover studies KU Leuven
Two replicate, double-blind, placebo-controlled, 6-week crossover studies assessed the effect of the once-daily long-acting β2-agonist olodaterol 5 μg and 10 μg on constant work-rate cycle endurance in patients with moderate to very severe chronic obstructive pulmonary disease.
Mediation analysis in AB/BA crossover studies Ghent University
Crossover trials are widely used in psychological and medical research to assess the effect of reversible exposures. In such designs, each subject is randomly allocated to a sequence of conditions, enabling the evaluation of treatment differences within each individual. When there are but two possible exposures -each assessed during one of two time periods-, the crossover study is referred to as an AB/BA design. The goal of this presentation is ...
Crossover studies with survival outcomes Ghent University
Intrapulmonary percussive ventilation improves lung function in cystic fibrosis patients chronically colonized with Pseudomonas aeruginosa: a pilot cross-over study Institute of Tropical Medicine Vrije Universiteit Brussel
High levels of shear stress can prevent and disrupt Pseudomonas aeruginosa biofilm formation in vitro. Intrapulmonary percussive ventilation (IPV) could be used to introduce shear stress into the lungs of cystic fibrosis (CF) patients to disrupt biofilms in vivo. We performed a first-of-its-kind pilot clinical study to evaluate short-term IPV therapy at medium (200 bursts per minute, bpm) and high frequency (400 bpm) as compared to autogenic ...
Evaluation of a flexible piecewise linear mixed-effects model in the analysis of randomized cross-over trials KU Leuven
Cross-over designs are commonly used in randomized clinical trials to estimate efficacy of a new treatment. They have received a lot of attention, particularly in connection with regulatory requirements for new drugs. The main advantage of using cross-over designs over conventional parallel designs is increased precision, thanks to within-subject comparisons. In the statistical literature, more recent developments are discussed in the analysis ...
Rivastigmine for ECT-induced cognitive adverse effects in late life depression (RECALL study): A multicenter, randomized, double blind, placebo-controlled, cross-over trial in patients with depression aged 55 years or older: Rationale, objectives and meth KU Leuven
BACKGROUND: Cognitive side-effects are an important reason for the limited use of electroconvulsive therapy (ECT). Cognitive side-effects are heterogeneous and occur frequently in older persons. To date, insight into these side-effects is hampered due to inconsistencies in study designs and small sample sizes. Among all cognitive side-effects, confusion and delirious states are especially troublesome for patients, relatives and clinicians. In ...
REMOVAL OF DIFFERENT CLASSES OF UREMIC TOXINS IN APD VS CAPD: A RANDOMIZED CROSS-OVER STUDY KU Leuven Ghent University
UNLABELLED: ♦ AIM: In this study, we investigated, and this for the different classes of uremic toxins, whether increasing dialysate volume by shifting from continuous ambulatory peritoneal dialysis (CAPD) to higher volume automated peritoneal dialysis (APD) increases total solute clearance. ♦ METHODS: Patients on peritoneal dialysis were randomized in a cross-over design to one 24-hour session of first a CAPD regimen (3*2 L of Physioneal 1.36% ...