Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis University of Antwerp
Background: Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown. Methods: We used an isogenic model of stepwise tumorigenic transformation of human primary cells to monitor the progressive deregulation ...