Publications
Predictive value of different covariates influencing pregnancy rate following intrauterine insemination with homologous semen: a prospective cohort study Hasselt University
Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort Vrije Universiteit Brussel University of Antwerp KU Leuven Ghent University
OBJECTIVE: To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients.
METHODS: We sequenced TBK1 in a hospital-based cohort of 482 unrelated patients with FTD and FTD-ALS and 147 patients with ALS and an extended Belgian FTD-ALS family DR158. We ...
Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients Vrije Universiteit Brussel KU Leuven University of Antwerp
BACKGROUND: ABCA7 was identified as a risk gene for Alzheimer's disease in genome-wide association studies (GWAS). It was one of the genes most strongly associated with risk of Alzheimer's disease in a Belgian cohort. Using targeted resequencing, we investigated ABCA7 in this cohort with the aim to directly detect rare and common variations in this gene associated with Alzheimer's disease pathogenesis.
METHODS: We did massive parallel ...
Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort Vrije Universiteit Brussel KU Leuven University of Antwerp
Rare variants in the phospholipase D3 gene (PLD3) were associated with increased risk for late-onset Alzheimer disease (LOAD). We identified a missense mutation in PLD3 in whole-genome sequence data of a patient with autopsy confirmed Alzheimer disease (AD) and onset age of 50 years. Subsequently, we sequenced PLD3 in a Belgian early-onset Alzheimer disease (EOAD) patient (N = 261) and control (N = 319) cohort, as well as in European EOAD ...
Mutations in glucocerebrosidase are a major genetic risk factor for Parkinson's disease and increase susceptibility to dementia in a Flanders-Belgian cohort Vrije Universiteit Brussel University of Antwerp
OBJECTIVE: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations.
METHODS: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well-characterized PD patients and 536 healthy control individuals.
RESULTS: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 ...
Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children int he ENVIRONAGE Birth Cohort Hasselt University KU Leuven Flanders Institute for Biotechnology
Pregnancy outcomes among Chinese women with and without systemic lupus erythematosus : a retrospective cohort study Ghent University
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries Vrije Universiteit Brussel KU Leuven
As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care.
Methods
We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death ...
Retrospective quarterly cohort monitoring for patients with visceral leishmaniasis in the Indian subcontinent: outcomes of a pilot project Institute of Tropical Medicine University of Antwerp
OBJECTIVE: To evaluate a new tool for the monitoring of Visceral Leishmaniasis (VL) treatment outcomes in primary healthcare (PHC) settings, adapted from the standardised Retrospective Quarterly Cohort Monitoring done in tuberculosis control.
METHODS: We developed standard case definitions for early and late VL treatment outcomes, a single register allowing for one-line entry per patient as registration tool, and quarterly reporting ...