Publications
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Validation of the nickel biotic ligand model for locally relevant species in Australian freshwaters Ghent University
Regulatory consideration of bioavailability for metals: simplification of input parameters for the chronic copper biotic ligand model Ghent University
Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia Ghent University
Mixture toxicity of copper and zinc to barley at low level effects can be described by the Biotic Ligand Model KU Leuven University of Antwerp Ghent University
Background and aims: The biotic ligand model (BLM) is a bioavailability model for metals based on the concept that toxicity depends on the concentration of metal bound to a biological binding site; the biotic ligand. Here, we evaluated the BLM to interpret and explain mixture toxicity of metals (Cu and Zn). Methods: The mixture toxicity of Cu and Zn to barley (Hordeum vulgare L.) was tested with a 4 days root elongation test in resin buffered ...
Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-F-tox approach KU Leuven
There are only a limited number of studies that have developed appropriate models which incorporate bioavailability to estimate mixture toxicity. Here, we explored the applicability of the extended biotic ligand model (BLM) and the WHAM-F(tox) approach for predicting and interpreting mixture toxicity, with the assumption that interactions between metal ions obey the BLM theory. Seedlings of lettuce Lactuca sativa were exposed to metal mixtures ...
Development of a biotic ligand model (BLM) predicting nickel toxicity to barley (Hordeum vulgare) Research Institute for Nature and Forest
A biotic ligand model (BLM) was developed to predict nickel toxicity, affecting root growth of barley (Hordeum vulgare), in nutrient solutions. The extent to which Ca2+, Mg2+, Na+, K+ ions and pH each influenced nickel toxicity was determined. Higher activities of Mg2+ linearly increased the 4 d EC50Nl2+, while Ca2+, Na+, K+ and H+ activities did not significantly influence Ni2+ toxicity. Stability constants for the binding of Ni2+ and Mg2+ to ...
Development and validation of a terrestrial biotic ligand model predicting the effect of cobalt on root growth of barley (Hordeum vulgare) Research Institute for Nature and Forest
A Biotic Ligand Model was developed predicting the effect of cobalt on root growth of barley (Hordeum vulgare) in nutrient solutions. The extent to which Ca2+, Mg2+, Na+, K+ ions and pH independently affect cobalt toxicity to barley was studied. With increasing activities of Mg2+, and to a lesser extent also K+, the 4-d EC50Co2+ increased linearly, while Ca2+, Na+ and H+ activities did not affect Co2+ toxicity. Stability constants for the ...
Combining a Standardized Batch Test with the Biotic Ligand Model to Predict Copper and Zinc Ecotoxicity in Soils KU Leuven
Extraction of soil samples with dilute CaCl2 solution in a routinely performed batch test has potential to be used in site-specific assessment of ecotoxicological risks at metal-contaminated sites. Soil extracts could potentially give a measure of the concentration of bioavailable metals in the soil solution, thereby including effects of soil properties and contaminant "aging." We explored the possibility of using a 0.001 M CaCl2 batch test ...