Publications
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Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease KU Leuven
The endothelium is the orchestral conductor of blood vessel function. Pathological blood vessel formation (a process termed pathological angiogenesis) or the inability of endothelial cells (ECs) to perform their physiological function (a condition known as EC dysfunction) are defining features of various diseases. Therapeutic intervention to inhibit aberrant angiogenesis or ameliorate EC dysfunction could be beneficial in diseases such as cancer ...
Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis University of Antwerp
Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stable and a vulnerable, rupture-prone lesion. The need for plaque-stabilizing therapies is high, and for a long time the lack of a ...
Angiogenesis in the central nervous system KU Leuven
Angiogenesis is critical for the development and repair, and contributes to disorders of the central nervous system (CNS). Identifying the signals that regulate CNS vascularization in health and disease offers novel opportunities to treat CNS disorders. We will review vascular development in the CNS (excluding in the retina, which is described in Chapter 44 on Ocular Neovascularization) in development and disease. © 2008 Springer US.
The role of PFKFB3 in tumor angiogenesis and vessel normalization KU Leuven
Endothelial cells (ECs) line blood vessels to supply oxygen and nutrients to tissues. Abnormal blood vessel growth (angiogenesis) promotes cancer growth and spread. Traditional anti-angiogenesis strategies rely on the inhibition of pro-angiogenic factors, primarily the growth factor vascular endothelial growth factor (VEGF). However, the efficacy of this treatment strategy is limited by intrinsic refractoriness. Those treatments attempt to ...
MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells KU Leuven
The healing of a fracture depends largely on the development of a new blood vessel network (angiogenesis) in the callus. During angiogenesis tip cells lead the developing sprout in response to extracellular signals, amongst which vascular endothelial growth factor (VEGF) is critical. In order to ensure a correct development of the vasculature, the balance between stalk and tip cell phenotypes must be tightly controlled, which is primarily ...
Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation KU Leuven
Blood vessel formation (angiogenesis) is crucial in physiology, but also contributes to pathologies (eg cancer, ocular disease). Various vascular (growth) factors controlling angiogenesis have been identified, a prominent example being the key endothelial cell (EC) growth factor VEGF. However, the host lab recently identified an entirely novel regulation of angiogenesis, relying on metabolic rewiring of the ECs to ensure generation of energy ...
Bringing regenerating tissues to life: the importance of angiogenesis in tissue engineering KU Leuven
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor ( FGF-2)/FGFR-2 pathway KU Leuven
The structural and catalytic requirements for neutrophil proMMP-9 to induce angiogenesis were investigated using a quantitative angiogenesis model based on grafting of collagen onplants onto the chorioallantoic membrane of chick embryos. Both physiological activation of neutrophil proMMP-9 and proteolytic activity of the generated MMP-9 enzyme were critically dependent on the TIMP-free status of proMMP-9 zymogen. The presence of an intact active ...
Crucial Role for Endothelial Cell α2β1 Integrin Receptor Clustering in Collagen-Induced Angiogenesis KU Leuven
Angiogenesis is a crucial mechanism of vascular growth and regeneration that requires biosynthesis and cross-linking of collagens in vivo and is induced by collagen in vitro. Here, we use an in vitro model in which apical Type I collagen gels rapidly induce angiogenesis in endothelial monolayers. We extend previous studies demonstrating the importance of the endothelial α2β1 integrin, a key collagen receptor, in angiogenesis by investigating the ...