Functional assessment and therapeutic targeting of a novel aortapathy syndrome with the strong potential to inform the pathogenesis and treatment of Marfan syndrome. University of Antwerp
Thoracic aortic aneurysm (TAA) entails a high risk for aortic dissection and rupture. The latter events are a prominent cause of morbidity and mortality in the Western population. Over the past 25 years, extensive gene discovery efforts have identified over 30 genes in which variants impinge on TAA risk. Although collectively explaining less than 30% of all familial patients, their identification and functional characterization have been key in ...