Hitting coronavirus replication in its core by combined inhibition of the nsp12 polymerase and associated proteins of the replication-transcription complex KU Leuven
The current COVID-19 vaccines do not prevent the appearance of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To treat infected risk groups and prepare against future zoonotic coronavirus (CoV) outbreaks, the development and stockpiling of pan-CoV therapeutics must be prioritized. In this project, we investigate a class of CoV lead inhibitors, recently identified in our laboratory and acting after onset of viral ...