Publications
Evaluation of response to neoadjuvant chemotherapy in osteosarcoma using dynamic contrast-enhanced MRI : development and external validation of a model Ghent University
ObjectiveTo identify which dynamic contrast-enhanced (DCE-)MRI features best predict histological response to neoadjuvant chemotherapy in patients with an osteosarcoma.MethodsPatients with osteosarcoma who underwent DCE-MRI before and after neoadjuvant chemotherapy prior to resection were retrospectively included at two different centers. Data from the center with the larger cohort (training cohort) was used to identify which method for ...
Diagnosis and monitoring denosumab therapy of giant cell tumors of bone : radiologic-pathologic correlation Ghent University
ObjectiveTo determine the value of CT and dynamic contrast-enhanced (DCE-)MRI for monitoring denosumab therapy of giant cell tumors of bone (GCTB) by correlating it to histopathology.Materials and methodsPatients with GCTB under denosumab treatment and monitored with CT and (DCE-)MRI (2012-2021) were retrospectively included. Imaging and (semi-)quantitative measurements were used to assess response/relapse. Tissue samples were analyzed using ...
The OMERACT whole-body MRI scoring system for inflammation in peripheral joints and entheses (WIPE) in spondyloarthritis- reference image atlas for the knee region Ghent University Flanders Institute for Biotechnology
Objective: To develop a reference image atlas for the Outcome Measures in Rheumatology whole-body MRI scoring system for inflammation in peripheral joints and entheses (OMERACT MRI-WIPE) of the knee region. Methods: Image examples of each pathology, location and grade, were collected and discussed at web-based, interactive meetings within the OMERACT MRI in Arthritis Working Group. Subsequently, reference images were selected by consensus. ...
Hip and pelvis region MRI reference image atlas for scoring inflammation in peripheral joints and entheses according to the OMERACT-MRI WIPE scoring system in patients with spondyloarthritis Ghent University Flanders Institute for Biotechnology
Objective: To develop a reference image atlas for scoring the hip/pelvis region according to the OMERACT wholebody MRI scoring system for inflammation in peripheral joints and entheses (MRI-WIPE). Methods: We collected image examples of each pathology, location and grade, discussed them at web-based, interactive meetings and, finally, selected reference images by consensus. Results: Reference images for each grade and location of osteitis, ...
Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA : post-hoc analysis of the CRESPA trial Ghent University Flanders Institute for Biotechnology
Objectives: The aim of this study was to investigate the reliability, validity, and sensitivity to change of a novel MRI scoring system in early peripheral SpA (pSpA). Methods: MRI of the pelvis and lower extremities was performed before initiation of the TNF inhibitor golimumab in 56 patients and repeated in 46 patients who achieved sustained clinical remission after 24, 36 or 48 weeks. Three readers applied a semi-quantitative MRI scoring ...
Magnetic resonance imaging of synovial tumor and tumorlike conditions Ghent University
Due to its unparalleled soft tissue resolution and multiplanar imaging capability, MRI is the modality of choice for imaging synovial tumor and tumorlike lesions. The minimal hardware requirements, imaging protocol, and either basic or advanced MR sequences are described. For lesion characterization, four major groups can be distinguished based on the analysis of signal intensities on T1- and T2-weighted images. Furthermore, this chapter gives ...
Clash of the titans : current CT and CT-like imaging modalities in sacroiliitis in spondyloarthritis Ghent University
Internal derangement of the knee : cartilage and osteochondral injuries Ghent University
Osteochondral lesions can be caused by osteochondritis dissecans, insufficiency fractures, and posttraumatic osteochondral fractures. It is sometimes impossible to differentiate among the three entities, as discussed in text. MRI, possibly with intravenous contrast agent administration, can unambiguously differentiate between stable and unstable osteochondritis dissecans based on the presence or absence of a high signal intensity line beneath ...
Plasmacytoma Ghent University
Solitary plasmacytoma of bone is one of many existing types of bone tumors and is part of the plasma cell disorder spectrum. It is a local clonal plasma cell proliferation without evidence of symptomatic multiple myeloma. It occurs slightly more frequently in males with a median age at diagnosis of 55 years. The thoracic vertebrae are most frequently involved. The exact etiology is unknown, although a role for acquired B-cell defects is ...