T1w/FLAIR ratio standardization as a myelin marker in MS patients Hasselt University KU Leuven
Introduction: Calculation of a T1w/T2w ratio was introduced as a proxy for myelin integrity in the brain of multiple sclerosis (MS) patients. Since nowadays 3D FLAIR is commonly used for lesion detection instead of T2w images, we introduce a T1w/FLAIR ratio as an alternative for the T1w/T2w ratio. Objectives: Bias and intensity variation are widely present between different scanners, between subjects and within subjects over time in T1w, T2w and ...