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Researcher

Vincent De Smet

  • Research interest:

    Liver fibrosis, cirrhosis and cancer are an increasing problem worldwide with a substantial global burden of disease. Liver fibrosis consists of a pathological deposition of extra-cellular matrix, which is produced by hepatic stellate cells who activate upon liver damage. When the liver injury is stopped, reversal of fibrosis is accompanied by inactivation of the HSCs. However, there is only limited knowledge on the mechanisms behind HSC inactivation. My PhD project focusses on sinusoidal cell communication to discover novel mechanisms of fibrosis development and reversal both in mice and human. Novel information gained from my PhD will fuel new treatment strategies for liver fibrosis.

  • Keywords:Medicine
  • Disciplines:Hepatology, Cellular interactions and extracellular matrix, Cell physiology
  • Users of research expertise:

    Liver fibrosis, cirrhosis and cancer are an increasing problem worldwide with a substantial global burden of disease. Liver fibrosis consists of a pathological deposition of extra-cellular matrix, which is produced by hepatic stellate cells who activate upon liver damage. When the liver injury is stopped, reversal of fibrosis is accompanied by inactivation of the HSCs. However, there is only limited knowledge on the mechanisms behind HSC inactivation. My PhD project focusses on sinusoidal cell communication to discover novel mechanisms of fibrosis development and reversal both in mice and human. Novel information gained from my PhD will fuel new treatment strategies for liver fibrosis.