Increased proximal reflux in a hypersensitive esophagus might explain symptoms resistant to proton pump inhibitors in patients with gastroesophageal reflux disease

Approximately 30% of patients with gastroesophageal reflux disease (GERD) have symptoms resistant to treatment with proton pump inhibitors (PPIs). Several mechanisms such as esophageal hypersensitivity, increased mucosal permeability and possibly the position of the gastric acid pocket might underlie a partial response to PPI. To what extent these mechanisms interact and contribute to PPI resistant symptoms has however not been investigated previously.

Publication year:2014

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:6

CSS-citation score:1

Authors:International

Authors from:Higher Education