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Understanding the consequences of aberrant epithelial function in allergic respiratory diseases

The general aim of this project is to better understand the role of the airway epithelium in allergic diseases, how allergens interact with epithelial cells, whether epigenetic changes underlie an altered epithelial function including defective barrier function, and what the consequences of this defect are on mucosal inflammatory responses. We hypothesize that a defective epithelial barrier (i.e. aberrant TLR signaling and/or epithelial permeability) may result from epigenetic changes due to chronic allergen exposure, which when established facilitate allergic sensitization and aggravate local inflammatory responses.

Date:6 Jan 2021 →  Today
Keywords:allergy, respiratory disease, inflammation
Disciplines:Allergology, Inflammation
Project type:PhD project