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Study of human lymphoid cell differentiation using gene-modified embryonic stem cells and induced pluripotent stem cells from immunodeficiency patients

Pluripotent stem cells will be generated from patients with an inborn immune (T/NK) deficiency. In addition, gene modified human embryonic stem cells will be generated for lineage tracing and deletion mutants. Using these cell lines T and NK differentiation will be studied and the effect of the targeted genes on differentiation will be analyzed.

Date:1 Jan 2011 →  31 Oct 2015
Keywords:immunity, hematopoiesis, immune deficiency, human, embryonic stem cells, gene targeting, induced pluripotent stem cells
Disciplines:Morphological sciences, Gynaecology and obstetrics, Molecular and cell biology, Genetics, Immunology