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Role of eicosanods in T-cell and dendritic cell activation in chronic rhinosinusitis/nasal polyposis with specialattention to aspirin exacerbated respiratory disease (AERD)

AERD constitute a severe form of airway inflammation within the group of patients with nasal polyposis and steroid-dependent asthma. We suggest that the development of the disease is linked to a disregulation of T-cell/DC function and an imbalance in the eicosanoid metabolism. The objective of the work is unravel the role of eicosanoids and aspirin desensitization on T-cel/DC differentiation/activation.

Date:1 Oct 2008 →  30 Sep 2015
Keywords:aspirin, dendritic cells, T-cells
Disciplines:Laboratory medicine, Otorhinolaryngology, Immunology, Speech, language and hearing sciences