The putative effect of corticostatin and neuropeptides belonging to the CRF-family on the interaction between visceral afferents, mast cells and dendritic cells during intestinal inflammation.

The aim of this project is (1) to verify whether CRF, UCN2 and UCN3, in addition to UCN1 and CST, also have anti-inflammatory effects on intestinal inflammation; (2) to determine, on the one hand, the effect of these neuropeptides on the neuroimmune interaction during inflammation and, on the other hand, the importance of this effect in the therapeutical effects of these neuropeptides; and (3) to examine which receptors are effectively involved in this process.

Keywords:INTESTINAL INFLAMMATION, CORTICOSTATIN, NEUROPEPTIDES

Disciplines:Microbiology, Systems biology, Gastro-enterology and hepatology, Immunology, Morphological sciences, Neurosciences, Veterinary medicine, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing

Project type:Collaboration project