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Plasma Abeta as endophenotype for genetic studies of Alzheimer dementia.
The aim of this project is to identify risk factors for Alzheimer dementia (AD), through studying the endophenotype Aß1-42 (in plasma). The use of Aß1-42 as outcome variable allows direct evaluation of the role of associated candidate genes in the amyloid cascade. Insight in the genetic variation of plasma Aß1-42 levels will in the long run contribute to targeted development of therapeutic and preventative strategies.
Date:1 Jan 2008 → 31 Dec 2010
Disciplines:Genetics, Systems biology, Molecular and cell biology, Neurosciences, Public health care, Public health sciences, Public health services, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing