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A microfluidics approach towards contact-free laser-induced photoporation for cell-based therapies (3E014617)

Laser-induced photoporation is new technology to efficiently deliver compounds into living cells. Here we address the challenge to photoporate cells without the sensitizing nanoparticles being in direct contact with the cell membrane in order to minimize cell toxicity. The technical realization is based on microfluidics, starting with computer simulations followed by the construction and evaluation of dedicated microfluidic chips.

Date:1 Oct 2017  →  30 Sep 2020
Keywords:biophotonics, photoporation, cell therapy, drug delivery, microfluidics
Disciplines:Pharmacology, Other (bio)medical engineering, Marine engineering, Drug discovery and development, Pharmacognosy and phytochemistry, Biological system engineering, Toxicology and toxinology, Pharmaceutics, Medical biotechnology, Geotechnical and environmental engineering, Biomechanical engineering, Biomarker discovery and evaluation, Biomaterials engineering, Pharmacotherapy, Medicinal products, Other pharmaceutical sciences