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Project
Metabolic potency of human intestinal microbiota towards ingested arsenic and consequences for microbe-host interactions
This research will provide a more complete risk assessment for oral exposure to arsenic. A new in vitro module with the co-culture of microorganisms and Caco-2 cells will provide unique and novel information on As speciation changes. Elucidating the mechanism behind microbial As metabolism in the gut may point towards strategies to mitigate the risks from oral As exposure.
Date:1 Oct 2007 → 30 Sep 2012
Keywords:gut microbiota, arseen, gut wall, mucosa
Disciplines:Laboratory medicine, Medicinal products, Pharmacognosy and phytochemistry, Nutrition and dietetics, Other chemical sciences, Gastro-enterology and hepatology, Pharmacotherapy, Systems biology, Agricultural animal production, Toxicology and toxinology, Public health care, Drug discovery and development, Biomarker discovery and evaluation, Pharmacology, Other pharmaceutical sciences, Microbiology, Food sciences and (bio)technology, Public health services, Pharmaceutics, Public health sciences, Environmental microorganism biotechnology