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Project
Mechanistic support of commercial health claims: implementation of a meta-genome analysis framework colonspecific in diet intervention study with pré- and probiotics (Type 3)- (IWT508)
The aim of this project is to develop a specific metageno-analysis framework aimed at the human colon that allows for changes within the colon microbiota - not only in terms of microbial diversity but also in terms of metabolic potential - during dietary intervention studies with functional food ingredients.
The project contains 5 objectives:
- The development of a colon-specific metabolic model that maps both saccharolytic and proteolytic colon reassortment processes.
- The development of a functional metageno-analysis framework by linking the metabolic model to a meta-analysis pipeline.
- The validation of the developed functional metageno-analysis framework using metagenomes obtained from both public databases and various international research projects in which the research group Bioinformatics and (Eco-) Systems Biology is closely involved.
- The implementation of the validated functional metageno-analysis framework in dietary intervention studies focused on the effect of the consumption of probiotics on healthy volunteers and individuals suffering from Irritable Bowel Syndrome, constipation or obesity.
- The identification of molecular metagenomombiomercers for welfare parameters that allow an objective evaluation of host well-being.
The project will result in 3 concrete achievements:
- The development of a publicly consulted, web-based, graphical user interface of the colon-specific, dynamic metabolic model of microbial fermentation processes.
- The development of a modular extension of existing meta-analysis pipelines, specifically aimed at monitoring shifts in metabolic activity and / or speciation composition within the colon microbiota.
- The identification of objective, molecular, metagenome-based biomarkers correlated with host well-being.
The project contains 5 objectives:
- The development of a colon-specific metabolic model that maps both saccharolytic and proteolytic colon reassortment processes.
- The development of a functional metageno-analysis framework by linking the metabolic model to a meta-analysis pipeline.
- The validation of the developed functional metageno-analysis framework using metagenomes obtained from both public databases and various international research projects in which the research group Bioinformatics and (Eco-) Systems Biology is closely involved.
- The implementation of the validated functional metageno-analysis framework in dietary intervention studies focused on the effect of the consumption of probiotics on healthy volunteers and individuals suffering from Irritable Bowel Syndrome, constipation or obesity.
- The identification of molecular metagenomombiomercers for welfare parameters that allow an objective evaluation of host well-being.
The project will result in 3 concrete achievements:
- The development of a publicly consulted, web-based, graphical user interface of the colon-specific, dynamic metabolic model of microbial fermentation processes.
- The development of a modular extension of existing meta-analysis pipelines, specifically aimed at monitoring shifts in metabolic activity and / or speciation composition within the colon microbiota.
- The identification of objective, molecular, metagenome-based biomarkers correlated with host well-being.
Date:1 Jul 2010 → 30 Nov 2011
Keywords:Applied Biology
Disciplines:Biological sciences