Innate imprinting of resident alveolar macrophages by allergic airway inflammation: mechanism and consequences for asthma exacerbation

In a mouse model of asthma, resident alveolar macrophages showed an increased inflammatory reactivity upon post-infection of the asthmatic lung. This project aims to elucidate the mechanism underlying the altered macrophage innate functionality and hereby to enable interference with asthma exacerbation.