The Flemish exposome project: towards a comprehensive understanding of the life-course impact ofdietary and environmental exposure on chronic low-grade gut inflammationAcronym = FLEXiGUT. (FLEXIGUT)

The human exposome covers the totality of non-genetic exposures from conception throughout the life course. The Flemish exposome project, FLEXiGUT, combines the unique and complementary expertise on dietary- and environment-related human biomarkers and biomonitoring, metabolomics,microbiome research and epidemiology to investigate the complex human exposome. This first largescale Flemish Exposome study will make use of biomonitoring and -omics based technologies on the available biological matrices of the Environage Birth and the Flemish Gut Flora cohorts. A specific focus will be on associations with chronic inflammation parameters and related diseases, analysed using an integrated -omics approach. Our pioneering results will be validated through extension towards other international cohorts.

Keywords:Exposome, human biomonitoring, metabolomics, microbiome, chronic exposure

Disciplines:Environmental health and safety, Epidemiology, Microbiome, Medical metabolomics, Other environmental sciences not elsewhere classified