Evolution and health implications of fine-scale sub-structure in human populations

How closely related are we to other people from our home town? How does distant relatedness of our parents have an impact on our health? This project uses genome-wide data from European populations to study population sub-structure and assortative mating patterns to estimate their effect on the accumulation of deleterious variants and their effect on fitness. This work will use evidence both from ancient and modern genomes to assess how kin-based sub-structure of populations has emerged and changed in the past and how it affects the variation of individual functional genes, including those associated with diseases.

Keywords:human populations

Disciplines:Medical imaging and therapy, Other paramedical sciences, Genetics, Systems biology, Molecular and cell biology