KLEOPATRA: Development and implementation of an effective combination of phages and antibiotics as an improved therapy against Klebsiella pneumoniae (KLEOPATRA)

The innovation objectives of the KU Leuven part of this project are the development of (i) a biobank of both capsule-specific and -independent phages that actively target Klebsiella strains isolated from a one health environment; (ii) new mathematical models for optimization of antimicrobial combinations in treatment protocols (in silico phagogram) and companion diagnostics for K. pneumoniae, as proof of concept for encapsulated pathogens. Valorization goals: (i) licensing of phages (ii) application of phages within UZ Leuven (iii) patenting of an in silico phagogram and mathematical model to define the best phage/antibiotic combinations for the treatment of a specific infection.