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Project
MOR(e) partners in crime: a bioassay approach to study μ-opioid receptor dimerization by new synthetic opioids
The emergence of new synthetic opioids (NSO) poses a serious threat to public health. This project aims at investigating the concept of μ-opioid receptor (MOR) dimerization, based on recent findings that a class of NSO induces MOR dimerization. An optimized MOR-MOR interaction assay will be developed, and the mechanisms of MOR dimerization will be elucidated via modelling of MOR dimers.
Date:1 Oct 2022 → 31 Oct 2022
Keywords:Structure-activity relationship, MOR dimerization, New Synthetic opioids, Bioassays
Disciplines:Forensic toxicology, Characterisation of biologically active (macro)molecules, Biomolecular modelling and design, Cell signalling