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Project
A juvenile pig model for pharmacokinetic studies of renally excreted drugs in critically ill children
Recent reports demonstrated that critically ill pediatric patients with sepsis often suffer augmented renal clearance (ARC). This leads to subtherapeutic plasma concentrations of renally excreted drugs and possible treatment failure. A juvenile pig model mimicking ARC will be developed to evaluate the pharmacokinetics of two frequently used antimicrobials (amoxicillin-clavulanic acid and amikacin) and to unravel the mechanism of ARC
Date:1 Oct 2016 → 30 Sep 2020
Keywords:Pigs
Disciplines:Drug discovery and development, Medicinal products, Pharmaceutics, Veterinary medicine, Paediatrics and neonatology, Biomarker discovery and evaluation, Pharmacognosy and phytochemistry, Nursing, Other agricultural, veterinary and food sciences, Pharmacotherapy, Pharmacology, Other pharmaceutical sciences, Animal biology, Other veterinary sciences, Toxicology and toxinology