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Project

Cargo identification and dynamic organization of the plant-specific TPLATE endocytic complex and its interplay with AP2

We recently identified the TPLATE complex as an essential endocytic complex driving plant clathrin-mediated endocytosis in plants alongside the evolutionary conserved AP-2 complex. Aim of this project is to link membrane proteins to either the TPLATE or the AP-2 complex and to further unravel the function of the TPLATE complex. This will be achieved using proximity biotinylation and conditional delocalization.

Date:1 Jan 2015 →  31 Dec 2020
Keywords:clathrin-mediated endocytosis, plant cell biology, protein complex purification, TPLATE complex
Disciplines:Plant genetics, Intracellular compartments and transport, Regulation of metabolism