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Project
Expedient purification of bioactive small molecules and/or their PEG conjugates using automated preparative HPLC
Generating compounds of high purity is an absolute necessity in medicinal chemistry. Only preparative HPLC allows us to purify adequate amounts of non crystalline material to an acceptable purity. Our laboratory is frequently highly dependent on HPLC purification. Access to a robust preparative HPLC system is crucial for the purification of several classes of molecules under development in our lab.
Date:1 Jun 2015 → 31 May 2017
Keywords:sulfated glycolipids, Preparative HPLC system, small molecules, medicinal chemistry, divalent GPCR ligands, polyethyleneglycol conjugates, phosphonates
Disciplines:Organic chemistry, Drug discovery and development, Toxicology and toxinology, Pharmacology, Biomarker discovery and evaluation, Pharmacognosy and phytochemistry, Other pharmaceutical sciences, Pharmaceutics, Small molecules, Medicinal chemistry