Role of Nanos and Pumilio family members in cancer progression

Transgenic mice with conditional expression of Nanos or PUM proteins will be bred to established mouse cancer models in order to analyze the effect of ectopic Nanos/PUM expression on tumor progression. Proteomic changes under the influence of tumor-associated Nanos and PUM will be identified. Transcription factor and miRNA networks regulating the expression of Nanos and PUM will be studied.