Glucocorticoid and selective glucocorticoid receptor modulator effects on tumour eco-system

The glucocorticoid receptor (GR), after binding to its ligand, functions as a transcription factor to regulate the expression of multiple target genes. Here we investigate the influence of GR and its ligands: glucocorticoids and selective GR modulators on the cross-talk between cancer cells and their surrounding stromal cells, an interaction known to affect cancer cell invasion via secreted products.