Human embryonic stem cells for bone tissue engineering

Pluripotent embryonic stem cells (ES) are able to differentiate into any cell type. The subject of this project is the differentiation of human ES into the osteogenic lineage. The following techniques will be applied: the use of osteogenic media with or without specific growth factors, the use of biomaterials and 3-dimensional cell constructs. If necessary, cells will be selected based on the expression of specific cell surface molecules.