Controlling the formation of osteoblast-osteocyte interactions by micropatterning to study bone cell mechanobiology.

Over the past 30 years, it has been extensively reported that bone cells are sensitive and responsive to mechanical stimulation. Mechanical cues promote bone strength whereas the lack of physical stimuli results in significant bone loss. However, despite many in vivo and in vitro studies, the molecular mechanisms through which bone cells communicate together to maintain bone tissue homeostasis in response to mechanostimulation are hardly understood. Therefore, we developed 2-dimensional (2D) bone cell arrays by robotic printing and cell micropatterning to study the mechanobiology of bone cells in communication with each other.

Publication year:2019

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