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Project
Can 3 months strength training counter chronic low-grade inflammation and improve immune function in older persons? (FWOAL987)
Aging is associated with both elevated circulating inflammatory
mediators, defined as a chronic low-grade inflammatory profile
(CLIP) and a reduced skin immunity. Physical exercise is one of the
best means to counter CLIP, and has shown to accelerate wound
healing in older adults. Exercise provokes an acute and brief
liberation of myokines, which induce an anti-inflammatory effect,
probably by stimulating the secretion of anti-inflammatory cytokines
by peripheral blood mononuclear cells (PBMCs). However, it remains
unclear whether exercise-induced changes in circulating immune
cells are representative for tissue-specific changes in
immunosenescence.
The overall aim of this project is to investigate if 3 months strength
training (ST) at different modalities can counter inflammation and
improve immune function in older persons. The project contains 3
major parts:
Part 1 aims to identify the effects of ST on the basal (i.e. nonstimulated) levels of inflammation and immunosenescence, both in
the circulation and at the tissue level.
Part 2 aims to verify whether ST affects the immune response after
both in vitro challenge on PBMC and in vivo challenge using an
innovative skin model.
Part 3 aims to determine if the effect of ST on inflammation and
immunosenescence is related to changes in well-being and
functionality.
The research project will pave the way to a novel and innovative invitro and in-vivo model to study exercise-induced anti-inflammation.
mediators, defined as a chronic low-grade inflammatory profile
(CLIP) and a reduced skin immunity. Physical exercise is one of the
best means to counter CLIP, and has shown to accelerate wound
healing in older adults. Exercise provokes an acute and brief
liberation of myokines, which induce an anti-inflammatory effect,
probably by stimulating the secretion of anti-inflammatory cytokines
by peripheral blood mononuclear cells (PBMCs). However, it remains
unclear whether exercise-induced changes in circulating immune
cells are representative for tissue-specific changes in
immunosenescence.
The overall aim of this project is to investigate if 3 months strength
training (ST) at different modalities can counter inflammation and
improve immune function in older persons. The project contains 3
major parts:
Part 1 aims to identify the effects of ST on the basal (i.e. nonstimulated) levels of inflammation and immunosenescence, both in
the circulation and at the tissue level.
Part 2 aims to verify whether ST affects the immune response after
both in vitro challenge on PBMC and in vivo challenge using an
innovative skin model.
Part 3 aims to determine if the effect of ST on inflammation and
immunosenescence is related to changes in well-being and
functionality.
The research project will pave the way to a novel and innovative invitro and in-vivo model to study exercise-induced anti-inflammation.
Date:1 Jan 2021 → Today
Keywords:Inflammageing, Strength training, Immunosenescence
Disciplines:Applied immunology, Biogerontology, Exercise physiology, Geriatrics