Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS

Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation. To what extent these molecules could also have a beneficial effect on TRPV1 sensitisation and visceral hypersensitivity (VHS), mechanisms involved in IBS, remains unknown.

Publication year:2021

Keywords:ION channels, abdominal pain, irritable bowel syndrome, neurogastroenterology, visceral hypersensitivity

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:10

Authors from:Higher Education

Accessibility:Open