Investigating a new molecular link between Wnt signaling and IGF1 in osteoarthritis

Osteoarthritis, the most prevalent joint disease, is characterized by joint damage that leads to pain and disability, and lacks curative treatment. In osteoarthritis, cartilage cells often develop abnormal differentiation towards hypertrophy, which contributes to joint destruction. These changes are associated with excessive activation of Wnt signaling. However, how Wnt signaling triggers hypertrophic differentiation is largely unknown. We have preliminary evidence that excessive Wnt increases local production of insulin growth factor- 1 (IGF1), a key player in the hypertrophy process. Here, we aim to investigate the molecular mechanism underlying this interaction and how this contributes to osteoarthritis. A successful project will lead to the identification of molecular events that trigger key disease-associated changes in cartilage, and may contribute to opportunities for osteoarthritis therapy.