Spatially multiplexed RNA and protein detection to study Alzheimer’s disease.

Alzheimer's disease (AD) is a major health problem worldwide. It has come to light that abnormal accumulation of amyloid beta peptides (Aβ) initiates complex multicellular alterations that progressively become Aβ independent and lead to brain dyshomeostasis. This complex cellular process in the proximity of amyloid-beta plaques will be studied in more detail using innovative technologies to spatially multiplexed RNA and protein detection in situ. Those advanced technologies open new possibility to reveal multicellular alterations with morphological and molecular information close to or far from amyloid plaques in parallel. The study of these cellular processes provides us new therapeutic targets which can disrupt or potentially reverse ongoing cellular processes and thus modify the disease progression.