Cationic polymers with controlled charge separation for non-viral RNA delivery

Nowadays, researchers can make synthetic self-amplifying messenger RNAs (sa-mRNAs) that encode for any desired protein. However, these synthetic RNAs require efficient carriers that protect and deliver them inside the cytoplasm of cells. In this project, we aim to develop cationic polymer transfection agents for in vitro and in vivo transfection of synthetic self-amplifying mRNAs.