Synaptic Dysfuntion mediated by Alzheimer's disease-relevant Microglia (SynDAM).

Recent evidence points to microglia, the central nervous system-resident macrophages, as mediators of synapse degeneration in AD. Our project aims to pinpoint the exact contribution of microglia to synapse (dys-)function by deploying an in vitro chimeric OSC platform as physiological model for functional studies of iPSC-derived human microglia, and by analysing the contribution of different microglia subpopulations to synaptic pruning in health and AD. This study will provide new hints on the protective/detrimental role of human microglial subpopulations and will be key to developing AD therapies that are capable of fine-tuning microglial composition in the beneficial direction.

Keywords:MICROGLIA, MICROSCOPY, SYNAPS, NEURODEGENERATION

Disciplines:Molecular and cell biology not elsewhere classified, Neurosciences not elsewhere classified, In vitro testing

Project type:Collaboration project