Ma.Tr.OC - Identification of molecular therapeutic targets and diagnostic/prognostic biomarkers of malignant transformation of osteochondromas.

This is a fundamental research project financed by the Research Foundation – Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.The molecular basis of peripheral chondrosarcoma development is are currently unknown. This leads to the lack of prognostic markers and, most importantly, the absence of a therapeutic approach alternative to the surgery.This project aims the identification of pathways underlying peripheral chondrosarcoma development and identify prognostic markers in patients with mutiple osteochondroma (MO), who are at increased risk of developing peripheral chondrosarcoma.

Keywords:OSTEOCHONDROMA, BIOMARKER, MEDICAL GENETICS

Disciplines:Genetics, Systems biology, Laboratory medicine, Medical systems biology, Molecular and cell biology