Bioimpedance Parameter Estimation using Fast Spectral Measurements and Regularizaton

This work proposes an alternative framework for parametric bioimpedance estimation as a powerful tool to characterize biological media. We model the bioimpedance as an electrical network of parallel RC circuits, and transform the frequency-domain estimation problem into a time constant domain estimation problem by means of the distribution of relaxation times (DRT) method. The fredholm integral equation of the first kind is employed to pose the problem in a regularized least squares (RLS) form. We validate the proposed methodology by numeral simulations for a synthetic biological electrical circuit, by using a multisine signal in the frequency range of 1kHz to 853kHz and considering an error in the-art techniques for spectral bioimpedance analysis. We also illustrate its potentiality in terms of accurate spectral measurements and precise data interpretation, for further usage in biological applications.

ISBN:2405-8963

Publication year:2018

Keywords:Biomedical Systems, Frequency Measurements, Impedance Spectroscopy, Parameter Estimation, Regression Algorithm, Spectrum Analysis

Accessibility:Open