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Digital quantification of Alzheimer's biomarker in biological samples
Book Contribution - Book Chapter Conference Contribution
© 15CBMS-0001. This manuscript reports a digital ELISA integrated on a digital microfluidics (DMF) platform for the ultrasensitive detection of Alzheimer's disease (AD) biomarker Tau protein over a wide range of relevant physiological concentrations. High-affinity antibodies combined with optimal assay conditions led to astonishing limits of detection in the low-attomolar range in buffer samples, which constitutes the first step toward developing a blood test for AD diagnosis.
Book: Proceedings of the 19th International Conference on Miniaturized systems for Chemistry and Life Sciences
Pages: 849 - 851
ISBN:9780979806483
Publication year:2015
Accessibility:Closed