Multidisciplinary study on implantation to improve IVF outcome

Infertility affects 5-8% of the population in developed countries. Infertility has various causes and remains unexplained in 1/3 couples due to a lack of knowledge on the development of a receptive endometrium and key processes of embryo implantation like decidualization and blastocyst adhesion. In addition, the chance on and the time to live birth achieved with in vitro fertilization depends on whether and how fast patients comply with treatment advice. This multidisciplinary project aims to provide important perceptions into the role of calcium permeable ion channels in the implantation process. Moreover, we will examine the role of TRPV2 in placental development and function. Finally, we will assess which characteristics of patients and of health care predict (the speed of) treatment compliance. This project will lead to novel fundamental insights into the implantation process and will be useful for the development of new clinical techniques in order to shorten the time-to life birth.

Keywords:Infertility, Embryo implantation, Calcium, Ion channels, IVF-discontinuation, Placentation, Receptive endometrium

Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences