Epigenetic modifications induced by critical illness with the muscle as paradigm (FKM/15)

We aim to demonstrate those epigenetic changes during critical illness, to examine how they are affected by metabolic factors, to study their long-term
persistence and their relation with functional status. Understanding the underlying molecular events will provide new opportunities for treatment and reduce the
burden of critical illness. In this project, we will use datasets and biopsy materials from 3 groups of intensive care patients. This project exemplifies a  ranslational research approach starting from a clinical question, bringing clinical observations towards laboratory experiments to finally integrate these data and contribute to better patient care.